|
KMID : 0616120100410040238
|
|
Korean Journal of Pharmacognosy
2010 Volume.41 No. 4 p.238 ~ p.244
|
|
|
Constituents of Cynanchum auriculatum and their Inhibitory Effect Melanogenesis in B16 Mouse Melanoma Cell Lines
|
|
Choi Hyun-Gyu
Kang Yan-Fu
Roh Eun-Mi-Ri
Kim Young-Soo
Xu Guang-Hua
Na Min-Kyun
Lee Seung-Ho
|
|
|
Abstract
|
|
|
|
Fourteen compounds were isolated from the roots of Cynanchum auriculatum and their chemical structures were identified as β-sitosterol (1), acetovanillone (2), p-hydroxyacetophenone (3), 2,4-dihydroxyacetophenone (4), 2,5-dihydroxyacetophenone (5), cynandione A (6), methyleugenol (7), daucosterol (8), Succinic acid (9), cynauriculoside A (10), wilfoside C3N (11), wilfoside C1N (12), wilfoside K1N (13) and wilfoside C1G (14). Among them, compounds 2-5 were isolated from this plant for the first time. And 2, 5-dihydroxyacetophenone (5) showed the most potent inhibitory effect on melanogenesis in B-16 mouse melanoma cell lines with IC50 value of 20 μM
|
|
|
KEYWORD
|
|
|
Cynanchum auriculatum, Melanogenesis, B16 cell lines, 2, 5-dihydroxyacetophenone
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|